Fervex Lemon Flavor (8 Sachets)
Fervex is a combination drug – containing three active substances, used in the immediate treatment of flu symptoms, colds and flu-like conditions in adults and adolescents over 15 years of age.
One sachet of Fervex granules contains:
- Paracetamol 500 mg has an analgesic and antipyretic effect.
- Pheniramine maleate 25 mg reduces congestion and swelling of mucous membranes, thus clearing the nasal passages, inhibiting the sneezing reflex and watery eyes.
- Ascorbic acid 200 mg replenishes vitamin C deficiency in the body. ghb1
Fervex is a drug in the form of granules intended for oral solution (the contents of the sachet should be dissolved in a glass of hot or cold water), usually 1 sachet is used 2 or 3 times a day, at intervals of at least 4 hours.
Fervex is used to treat the symptoms of flu, colds and flu-like conditions (headache, fever, nasopharyngitis) in adults and children over 15 years of age.
Antibiotic treatment may be required if a bacterial infection occurs. The attending physician will decide about it.
Active substance: Acidum ascorbicum, Paracetamolum, Pheniramini maleas
|Active substances||One sachet contains:
Paracetamol 500 mg
Ascorbic acid 200 mg
Pheniramine maleate 25 mg
|The other ingredients||sucrose (11.5 g), citric acid anhydrous, acacia gum, sodium saccharin, lemon-rum flavor.|
How to dose Fervex?
Dosage of Fervex in adults and children over 15 years of age:
- 1 sachet 2 or 3 times a day.
- Interruptions in the administration of subsequent doses should be at least 4 hours.
The contents of the Fervex sachet should be dissolved in a glass of hot or cold water.
Do not use for more than 5 days without consulting a doctor.
In the treatment of flu-like conditions, it is better to take the medicine dissolved in hot water in the evening, as soon as possible after symptoms appear.
In case of impaired renal function (creatinine clearance less than 10 ml / min), an interval of at least 8 hours between doses should be observed.
When should you not use Fervex?
- Hypersensitivity (allergy) to the active substances or any of the excipients.
- Severe liver or kidney failure.
- Narrow-angle glaucoma.
- An enlarged prostate with difficulty urinating.
- Age under 15.
- Fervex should not be used in patients with fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency due to the sucrose content in the drug.
Do not use Fervex for more than 5 days without your doctor’s advice.
The risk of addiction, mainly psychological, is mainly observed in the case of higher doses than recommended and in the case of long-term treatment.
In order to avoid the risk of overdose, check that other medicines you are taking do not contain paracetamol. For adults weighing more than 50 kg, the TOTAL DAILY DOSE OF PARACETAMOL MUST NOT BE MORE THAN 4 GRAMS.
Drinking alcoholic beverages or taking sedatives (especially barbiturates) increases the sedative effect of antihistamines, so concomitant use should be avoided.
Paracetamol should be used with caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
Each sachet of Fervex contains 11.5 g of sucrose, therefore, in the case of diabetic patients, the presence of sugar in the drug should be taken into account.
Caution should be exercised when administering Fervex to people with impaired kidney function.
In the case of diabetics, the presence of sugar in the drug, the content of which is 11.5 g in one sachet, should be taken into account.
Fervex in pregnancy
- The use of Fervex during pregnancy is not recommended.
- The use of Fervex while breastfeeding is not recommended.
Drowsiness may occur while taking Fervex, which may affect the psychophysical fitness of people driving motor vehicles and operating machines.
Fervex and other drug interactions
Due to the content of pheniramine
Not recommended connections:
- alcohol (due to the pheniramine content): Alcohol increases the sedative effect of most antihistamines – H1 receptor antagonists. Changes in attention span may impair the ability to drive or operate machinery.Avoid taking alcoholic beverages or medications that contain alcohol.
Combinations that should be used with caution
- other sedative drugs (due to the pheniramine content): morphine derivatives (analgesics, antitussives), neuroleptics, barbiturates, benzodiazepines, anxiolytics other than benzodiazepines (e.g. meprobamate), hypnotics, sedative antidepressants (amitriptyline) , mianserin, mirtazapine, trimipramine), sedative H1 antihistamines , centrally acting antihypertensives, baclofen and thalidomide.Increased inhibition of the central nervous system and the related changes in the ability to concentrate attention may impair the ability to drive vehicles and operate moving mechanisms.
- other drugs with an atropinic effect (due to the pheniramine content): antidepressants with a structure similar to imipramine, most antihistamines that block the H1 receptor, anticholinergic antiparkinsonian drugs, atropine-like drugs with antispasmodics, disopyramide, phenothiazine derivative neuroleptics, clozapine.Aggregation of atropine-like side effects such as urinary retention, constipation, and dry mouth.
Due to the paracetamol content
- Salicylamide increases the elimination time of paracetamol.
- Rifampicin, antiepileptic drugs, barbiturate hypnotics and other microsomal enzyme inducers used in conjunction with paracetamol increase the risk of liver damage.
- Caffeine enhances the analgesic and antipyretic effects of paracetamol.
- Concomitant use of high doses of paracetamol and non-steroidal anti-inflammatory drugs may increase the risk of renal dysfunction.
- Paracetamol enhances the effect of oral anticoagulants from the coumarin group.
- Paracetamol used with MAO inhibitors may cause agitation and high fever.
- Effect on laboratory tests performed: administration of paracetamol may affect the results of blood uric acid tests performed by a method involving the use of phosphor-tungsten acid; as well as to test the glucose level with the oxidase-peroxidase method.
- may reduce the effectiveness of warfarin and the plasma concentration of fluphenazine,
- reduces urine pH, which may affect the elimination of other, concomitantly administered drugs.
Like all medicines, FERVEX can cause side effects:
RELATED TO PHENRAMINE
Undesirable effects may vary in severity, depending on the dose and not depending on the dose:
- Neurovegetative actions:
- sedation or somnolence, which is more severe when starting treatment,
- anticholinergic symptoms such as dry mucous membranes, constipation, accommodation disturbances, pupil dilation, palpitations, risk of urinary retention,
- orthostatic hypotension,
- balance problems, dizziness, problems with memory or concentration, more often in the elderly,
- impaired motor coordination, tremors,
- confusion, hallucinations
- less frequent symptoms of the type of agitation: restlessness, nervousness, insomnia.
- Hypersensitivity reactions (rare):
- erythema, itching, eczema, purpura, urticaria,
- swelling, less often Quincke’s edema (swelling of the lips, tongue or larynx),
- anaphylactic shock (a type of systemic immediate-type allergic reaction with impaired circulation and respiration).
- Symptoms of the hematopoietic system:
- leukocytopenia (reduced number of white blood cells), neutropenia (reduced number of granulocytes),
- thrombocytopenia (low blood platelet count),
- hemolytic anemia.
RELATED TO PARACETAMOL:
- Few cases of hypersensitivity reactions such as anaphylactic shock, Quincke’s edema, erythema, urticaria and skin rash have been reported. If any of these symptoms occur, treatment with this medicine and medicines of a similar composition should be stopped immediately.
Some people may experience other side effects while taking FERVEX.
If you experience other side effects, not mentioned in this leaflet, please inform your doctor about them.
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