Description: Polopiryna Complex is a multi-ingredient medicine that combats cold symptoms such as fever, muscle and joint pain, and runny nose.
Composition: The active ingredients in the medicine are acetylsalicylic acid (Acidum acetylsalicylicum), phenylephrine bitartrate (Phenylephrini bitartras), and chlorphenamine maleate (Chlorphenamini maleas).
Each sachet contains 500 mg of acetylsalicylic acid, 15.58 mg of phenylephrine bitartrate, and 2 mg of chlorphenamine maleate.
Excipients: colloidal anhydrous silica, sucrose, sodium saccharin, sodium cyclamate, anhydrous citric acid, orange flavor.
Dosage: This medicine should always be taken according to the instructions in the patient leaflet or as directed by a doctor or pharmacist. In case of doubt, consult a doctor or pharmacist.
Adults and adolescents over 16 years old:
1 sachet every 6-8 hours as needed. Do not exceed a dose of 4 sachets per day.
Dissolve the contents of one sachet in a glass of hot water, mix, and drink. Take orally as a hot drink. Taking the medicine at the lowest effective dose for the shortest necessary period reduces the risk of side effects. In elderly patients (over 65 years old), the medicine should be used in lower doses and at longer intervals due to the increased risk of adverse effects in this patient group.
Action: Polopiryna Complex combines the effects of three components. Thanks to them, it comprehensively alleviates cold symptoms.
Acetylsalicylic acid acts as an antipyretic, analgesic, and anti-inflammatory. Phenylephrine reduces congestion and swelling of the mucous membranes, thereby clearing nasal passages, inhibiting the sneezing reflex, and reducing eye watering. Chlorphenamine relieves symptoms of nasal congestion (runny nose and sneezing). Buffering agents in the medicine enable rapid and complete dissolution of Polopiryna Complex in water, making it easily absorbed and well-tolerated.
Indications: Polopiryna Complex is used in the comprehensive treatment of cold and flu symptoms such as:
Fever, Chills, Sore throat, Muscle and joint pain, Headache (caused by reduced patency of the nasal sinuses due to swelling of the nasal mucosa and restricted airflow), Nasal mucosa swelling and congestion, Excessive nasal mucus production, Sneezing, Watery eyes.
Contraindications: Do not use Polopiryna Complex:
If the patient is allergic to acetylsalicylic acid or any other ingredient in this medicine. Hypersensitivity to acetylsalicylic acid occurs in 0.3% of the population, including 20% of patients with bronchial asthma or chronic urticaria. Symptoms of hypersensitivity, such as urticaria or even shock, may occur within 3 hours of taking acetylsalicylic acid.
If the patient is allergic (hypersensitive) to other nonsteroidal anti-inflammatory drugs, accompanied by symptoms such as bronchial spasm, hay fever, or shock. If the patient has bronchial asthma, chronic respiratory system disorders, hay fever, or nasal mucosa swelling, as patients with these conditions may react to nonsteroidal anti-inflammatory drugs with asthma attacks, limited skin and mucosal edema (angioedema), or urticaria more often than other patients. If the patient has active gastric or duodenal ulcer disease and (or) inflammatory or bleeding conditions of the gastrointestinal tract (there may be gastrointestinal bleeding or exacerbation of ulcer disease). If the patient has severe liver, kidney, or heart failure. If the patient has blood clotting disorders (e.g., hemophilia, thrombocytopenia) and is being treated with anticoagulants at the same time (e.g., coumarin derivatives, heparin). If the patient has glucose-6-phosphate dehydrogenase deficiency (a rare inherited disease). If the patient is simultaneously taking methotrexate in doses of 15 mg per week or more, due to its harmful effects on bone marrow. In children under 16 years old, especially during viral infections, due to the risk of Reye’s syndrome, a rare but severe disease causing liver and brain damage. If the patient is pregnant or breastfeeding. If the patient has cardiovascular disease, hypertension. If the patient has diabetes. If the patient has closed-angle glaucoma. If the patient has thyroid hyperactivity. If the patient has prostate enlargement. If the patient has a pheochromocytoma (chromaffin cell tumor of the adrenal medulla). If the patient is taking monoamine oxidase inhibitors (MAOIs) or within 14 days after discontinuation of MAOI therapy.
Adverse reactions: Like any medication, Polopiryna Complex can cause adverse reactions, although not everyone will experience them.
After using acetylsalicylic acid, isolated cases of bleeding disorders, such as prolonged bleeding time, have been reported. The following adverse reactions are classified according to the system organ class and frequency: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), or unknown frequency.
Blood and lymphatic system disorders: Uncommon: prolonged bleeding time. Rare: anemia, bleeding disorders (such as prolonged bleeding time), thrombocytopenia, neutropenia, eosinophilia. Very rare: agranulocytosis.
Immune system disorders: Very rare: hypersensitivity reactions, including angioedema, bronchospasm, rhinitis, rash, pruritus, urticaria.
Metabolism and nutrition disorders: Uncommon: hypoglycemia. Rare: hyperkalemia.
Psychiatric disorders: Rare: confusion.
Nervous system disorders: Common: headache. Uncommon: dizziness. Rare: intracranial bleeding.
Eye disorders: Very rare: impaired vision, tinnitus. Very rare: hearing loss.
Respiratory, thoracic, and mediastinal disorders: Very rare: bronchospasm in patients with hypersensitivity to aspirin or NSAIDs, asthma (including aggravated asthma), cough, dyspnea, rhinitis, nasal mucosa swelling (edema), nasal congestion.
Gastrointestinal disorders: Common: nausea. Uncommon: gastric ulcer, duodenal ulcer, gastrointestinal bleeding, gastritis, vomiting, diarrhea. Rare: peptic ulcer perforation.
Hepatobiliary disorders: Very rare: liver function disorders, hepatitis. Very rare: elevated liver enzymes.
Skin and subcutaneous tissue disorders: Common: rash, urticaria. Uncommon: pruritus. Rare: Stevens-Johnson syndrome, Lyell’s syndrome. Very rare: photosensitivity, purpura.
Renal and urinary disorders: Very rare: renal dysfunction, interstitial nephritis, renal failure.
General disorders and administration site conditions: Common: bleeding (including skin and mucosal bleeding). Uncommon: edema. Rare: fatigue.
Overdose: Acetylsalicylic acid overdose may cause salicylism, with symptoms such as dizziness, tinnitus, deafness, sweating, nausea, vomiting, headache, confusion, and metabolic acidosis. Severe poisoning can cause delirium, hallucinations, respiratory failure, cardiovascular collapse, seizures, coma, and death.
Phenylephrine overdose can cause symptoms such as headache, high blood pressure, rapid heartbeat, palpitations, and vomiting.
Chlorphenamine overdose may result in symptoms such as dry mouth, blurred vision, urinary retention, hallucinations, seizures, and respiratory depression.
In case of an overdose, consult a doctor immediately.
Storage: Store at a temperature below 25°C (77°F). Keep out of reach of children.
Presentation: Polopiryna Complex is available in sachets containing granules for oral solution. Each box contains 12 sachets.
Manufacturer: Polpharma S.A. ul. Pelplińska 19 83-200 Starogard Gdański Poland
Date of last revision: June 2022
